Scientific Publications
Clinical outcomes of Staphylococcus capitis isolation from neonates, England, 20152021: a retrospective case-control study
Archives of Disease in Childhood
Abstract Objective Staphylococcus capitis, a coagulase-negative staphylococci (CoNS), has been increasingly detected from UK sterile site samples and has caused neonatal unit outbreaks worldwide. We compared survival to discharge and 30-day mortality for detections of S. capitis versus other CoNS species. Methods In this retrospective case-control study, we included hospitalised infants with any CoNS species detected from a normally-sterile body site up to 90 days of age. We linked English laboratory reports from the Second Generation Surveillance System database, mortality data from the Personal Demographics Service, and neonatal unit admissions from the National Neonatal Research Database. In primary analysis, multivariable logistic regression was used, with two co-primary outcomes: survival to discharge and death within 30 days of positive specimen date. Sensitivity analyses using multiply imputed datasets followed. Results CoNS detections were highest among infants born extremely preterm (22-27 weeks) and with extremely low birth weight (400-999g). In primary analysis, there were no differences in survival to discharge or death at 30 days between CoNS species. In sensitivity analyses, there were no differences in outcomes between infection with four of the commonest CoNS species (S. epidermidis, S. capitis, S. haemolyticus and S. warneri) but the remaining CoNS species were at higher risk of adverse outcomes when treated in aggregate. Conclusions Infants with S. capitis detected from sterile site samples did not experience significant differences in either survival to discharge or 30-day mortality compared to infants with detections of other common CoNS species
Archives of Disease in Childhood
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