Copper is an intestinal habitat filter affecting the gut microbiota interactions with Salmonella Typhimurium.

Kolenda R, Hassan MM, Arrieta-Gisasola A, Kamara A, Ansorge R, Sidorczuk K, Acton L, Thilliez G, Baker DJ, Burdukiewicz M, Stares MD, Browne HP, Le Gall, Torres RC, Chavez-Arroyo A, Garrett J, Stevens MP, Lawley TD, Bäumler AJ, La Ragione, Hildebrand F, Kingsley RA. (2026)

Microbiome

Foodborne pathogens, including Salmonella enterica serovar Typhimurium (S. Typhimurium), pose a significant threat to both human health and livestock productivity. The pandemic S. Typhimurium ST34 clone acquired a genomic island (SGI-4) conferring high copper resistance, an adaptation relevant in the context of the widespread use of copper sulphate at therapeutic levels in pig farming. We investigated how high dietary copper influences the piglet gut microbiota and Salmonella-microbiota interactions that may explain the global spread of S. Typhimurium ST34.

Microbiome

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