Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial.

Guglielmetti S., Bernardi S., Del Bo' C., Cherubini A., Porrini M., Gargari G., Hidalgo-Liberona N., Gonzalez-Dominguez R., Peron G., Zamora-Ros R., Winterbone M. S., Kirkup B., Kroon P. A., Andres-Lacueva C., Riso P.. (2020)

BMC geriatrics, 20, 77

During aging, alterations of the intestinal microbial ecosystem can occur contributing to immunosenescence, inflamm-aging and impairment of intestinal barrier function (increased intestinal permeability; IP). In the context of a diet-microbiota-IP axis in older subjects, food bioactives such as polyphenols may play a beneficial modulatory role.

BMC geriatrics, 20, 77

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