Exploring Endotypes in Chronic Rhinosinusitis (ExpRess): Protocol for a cohort study.

Gokani SA, Jefferson M, Gavrilovic J, Clark A, Hildebrand F, Wileman T, Hopkins C, Philpott . (2023)

PloS one

Chronic Rhinosinusitis (CRS) affects approximately 1 in 10 UK adults and impacts quality of life quality of life significantly. Response to treatment may be driven by individual CRS endotypes and therefore work to delineate biomarker clusters that may separate responders from non-responders is needed. The ongoing MACRO three-arm parallel-group trial randomises adult CRS patients to endoscopic sinus surgery, macrolide therapy or placebo.

PloS one

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