Scientific Publications
Genomes, neurotoxins and biology of Clostridium botulinum Group I and Group II
Research in Microbiology, 166, 303-317
Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of C. botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches to the study of genomics in these bacteria are compared; comparative whole genome microarrays and direct comparison of complete genome DNA sequences. The properties of the different types of neurotoxin formed, and different neurotoxin gene clusters found in C. botulinum Groups I and II are explored. Specific examples of botulinum neurotoxin gene are chosen for an in-depth discussion of neurotoxin gene evolution. The most recent cases of foodborne botulism are summarised.
Research in Microbiology, 166, 303-317
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