Host immunogenetic variation and gut microbiome functionality in a wild vertebrate population.

Lee CZ, Worsley SF, Davies CS, Komdeur J, Hildebrand F, Dugdale HL, Richardson DS. (2026)

Microbiome


The gut microbiome (GM) -important for host health and survival- is partially shaped by host immunogenetics. However, to date, no study has investigated the influence of host Major Histocompatibility Complex (MHC) genes on gut microbiome functionality in a wild population. Here we use a natural population of the Seychelles warbler (Acrocephalus sechellensis) to assess the effects of MHC genes on GM taxonomy and functionality using shotgun metagenomics.


Microbiome


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