Hyaluronic acid modulates gut microbiota and metabolites relieving inflammation: A molecular weight-dependent study.

Zhang C, Wang B, Yu L, Zhao R, Zhang Q, Zhang C, Cui S, Zhao J, Narbad A, Chen W, Tian F, Zhai Q. (2024)

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this study employed in vivo animal and in vitro fermentation models in conjunction with microbiome and metabolomic analyses to elucidate changes in the gut microbial network and associated metabolite effects involved in alleviating host inflammation by HA of varying molecular weights. This research contributes to a deeper understanding of the intricate interplay between HA regulation of host gut microbiota and inflammatory processes, thereby offering therapeutic potential for targeted immunotherapy based on gut microbiota

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