Interleukin-22 orchestrates a pathological endoplasmic reticulum stress response transcriptional programme in colonic epithelial cells.

Powell N., Pantazi E., Tsakmaki A., Pavlidis P., Li K., Yang F., Parker A., Pin C., Cozzetto D., Minns D. H., Stolarczyk E., Saveljeva S., Mohamed R., Lavender P., Afzali B., Digby-Bell J., Tsui T. L., Kaser A., Friedman J., MacDonald T. T., Bewick G. A., Lord G. M.. (2019)

Gut

The functional role of interleukin-22 (IL22) in chronic inflammation is controversial, and mechanistic insights into how it regulates target tissue are lacking. In this study, we evaluated the functional role of IL22 in chronic colitis and probed mechanisms of IL22-mediated regulation of colonic epithelial cells.

Gut

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