Intestinal Sirtuin 1 controls liver regeneration via regulating the intestinal FXR/FGF15 axis in mice.

Seaman S, Ruiz P, Dias-Nirello V, Martin-Castilla L, Elizalde-Garcia P, Vega-Zuza A, Vegas-Petrina L, Lumbreras-Perales C, Philo M, Moreno-Gonzalez M, Varga-Weisz P, Beraza N. (2026)

Cellular and molecular gastroenterology and hepatology

The contribution of the gut-liver axis during liver regeneration remains poorly understood. Understanding the mechanisms underlying this process is critical for developing novel therapeutic strategies for liver diseases and transplantation. Here, we aimed at defining the role of intestinal Sirtuin-1 (SIRT1) during liver regeneration in mice.

Cellular and molecular gastroenterology and hepatology

View Publication