Lack of the host membrane protease FtsH hinders release of the Lactococcus lactis bacteriophage TP712

Wegmann U., Roces C., Campelo A., García P., Rodríguez A., Martínez B.. (2013)

Journal of General Virology, 94, 28142818

The temperate bacteriophage TP712 was unable to plate on Lactococcus lactis ΔftsH lacking the membrane protease FtsH and complementation in trans restored the wild-type phenotype. Absence of ftsH did not hinder phage adsorption, phage DNA delivery or activation of the lytic cycle. Thin sections revealed that TP712 virions appeared to be correctly assembled inside the ΔftsH host but were not released. These virions were infective, demonstrating that a functional host FtsH is required by TP712 to effectively proceed with lysis of the host.

Journal of General Virology, 94, 28142818

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