Metabolic regulation of macrophages by SIRT1 determines activation during cholestatic liver disease in mice.

Isaacs-Ten A, Moreno-Gonzalez M, Bone C, Martens A, Bernuzzi F, Ludwig T, Hellmich C, Hiller K, Rushworth SA, Beraza N. (2021)

Cellular and molecular gastroenterology and hepatology

Inflammation is the hallmark of chronic liver disease. Metabolism is a key determinant to regulate the activation of immune cells. Here we define the role of Sirtuin1 (SIRT1), a main metabolic regulator, in controlling the activation of macrophages during cholestatic liver disease and in response to endotoxin.

Cellular and molecular gastroenterology and hepatology

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