Molecular structure-function relationship of dietary polyphenols for inhibiting VEGF-induced VEGFR-2 activity.

Cerezo A. B., Winterbone M. S., Moyle C. W. A., Needs P. W., Kroon P. A.. (2015)

Molecular Nutrition and Food Research, 59, 2119-2131

We recently reported potent inhibition of VEGF signalling by two flavanols at sub-micromolar concentrations, mediated by direct binding of the flavanols to VEGF. The aim of this study was to quantify the inhibitory potency and binding affinity of a wide range of dietary polyphenols and determine the structural requirements for VEGF inhibition.

Molecular Nutrition and Food Research, 59, 2119-2131

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