Monomeric Flavanols are More Efficient Substrates for gut Microbiota Conversion to Hydroxyphenyl- ?-Valerolactone Metabolites than Oligomeric Procyanidins: A Randomized, Placebo-Controlled Human Intervention Trial.

Hollands W. J., Philo M., Perez-Moral N., Needs P. W., Savva G. M., Kroon P. A.. (2020)

Molecular nutrition & food research, Yes, e1901135

The majority of ingested flavanols reach the colon where they are catabolised by the microbiota to form derivatives of hydroxyphenyl-?-valerolactones (HGVLs). It is not known if the HGVLs are catabolic products of monomeric catechins, oligomeric procyanidins (PC), or both. Using data from a randomized, double-blind, placebo-controlled, crossover trial we estimated the relative contributions of catechins and PC to the bioavailable pool of HGVLs.

Molecular nutrition & food research, Yes, e1901135

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