Morphology of bile salts micelles and mixed micelles with lipolysis products, from scattering techniques and atomistic simulations.

Pabois O,Ziolek RM,Lorenz CD,Prévost S,Mahmoudi N,Skoda MWA,Welbourn RJL,Valero M,Harvey RD,Grundy MM,Wilde PJ,Grillo I,Gerelli Y,Dreiss CA. (2021)

Journal of colloid and interface science, 587, 522-537

Bile salts (BS) are biosurfactants released into the small intestine, which play key and contrasting roles in lipid digestion: they adsorb at interfaces and promote the adsorption of digestive enzymes onto fat droplets, while they also remove lipolysis products from that interface, solubilising them into mixed micelles. Small architectural variations on their chemical structure, specifically their bile acid moiety, are hypothesised to underlie these conflicting functionalities, which should be reflected in different aggregation and solubilisation behaviour.

Journal of colloid and interface science, 587, 522-537

View Publication