Need for standardised vancomycin dosing for coagulase-negative staphylococci in hospitalised infantsAuthorsEleanor J. HarveyDiane Ashiru-OredopeLouise F. HillUKHSA Staphylococcus capitis Incident Management TeamEpidemiology groupElita JauneikaiteYu WanRussell HopeAndrew RobbLouise ThornPaul FlemingBruno PichonEnvironment and equipment groupDerren ReadyMustafa ElsayedHeather FelgateGinny MooreClinical management groupSantosh PattnayakSakina AliTed GasiorowskiTimothy WattsLouise WoosterVicky PayneColin BrownAlleyna ClaxtonChristina KortsalioudakiMitul PatelNabeela MughalOlga MoncayoSujoy BanerjeeLiz McKechnieRashmi GandhiGuidance groupRhys DCostaMinesh KhashuNatasha RatnarajaKavita SethiSimon DrysdaleBharat PatelAlicia Demirjian 

. (2022)

Clinical Microbiology and Infection, 29, 10-12

In high-income countries, coagulase-negative staphylococci (CoNS) are the most commonly implicated pathogens in late-onset sepsis (LOS; sepsis occurring after 72 hours of age) in neonates. They are responsible for over half of neonatal LOS cases. Overall mortality rates from LOS caused by CoNS are low, however, low birthweight and preterm infants carry the highest burden. Morbidity related to LOS caused by CoNS has been associated with poor neurodevelopment, visual impairment, chronic lung disease, and necrotising enterocolitis, and can prolong length of hospitalisation. CoNS are frequently multi-drug resistant and the emergence of the multidrug resistant Staphylococcus capitis NRCS-A clone worldwide, found almost exclusively as a pathogen within neonatal units, is concerning. A recent survey of French neonatal units demonstrated that S. capitis accounted for 14.2% of nosocomial bloodstream infections, with the majority being attributed to the NRCS-A clone.

Clinical Microbiology and Infection, 29, 10-12

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