Placental endocrine function is controlled by maternal gut Bifidobacterium in germ-free mice.

Lopez-Tello J, Kiu R, Schofield Z, Dalby MJ, van Sinderen, Gall GL, Hall LJ, Sferruzzi-Perri AN. (2025)

Journal of translational medicine

Recent studies have shown that the maternal gut microbiota can regulate placental growth, particularly the transport region, in association with fetal growth. However, the specific role of certain microorganisms in modulating the hormonal production of the placenta, which is critical for supporting fetal development and maintaining a healthy pregnancy, remains largely unexplored. In this context, the objective of this study is to determine whether the maternal colonisation with the early life gut bacterium Bifidobacterium breve UCC2003 regulates placental endocrine function.

Journal of translational medicine

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