Probiotic and Functional Properties of Limosilactobacillus reuteri INIA P572.

Diez-Echave P,Martín-Cabrejas I,Garrido-Mesa J,Langa S,Vezza T,Landete JM,Hidalgo-García L,Algieri F,Mayer MJ,Narbad A,García-Lafuente A,Medina M,Rodríguez-Nogales A,Rodríguez-Cabezas ME,Gálvez J,Arqués JL. (2021)

Nutrients

Limosilactobacillus reuteri INIA P572 is a strain able to produce the antimicrobial compound reuterin in dairy products, exhibiting a protective effect against some food-borne pathogens. In this study, we investigated some probiotic properties of this strain such as resistance to gastrointestinal passage or to colonic conditions, reuterin production in a colonic environment, and immunomodulatory activity, using different in vitro and in vivo models. The results showed a high resistance of this strain to gastrointestinal conditions, as well as capacity to grow and produce reuterin in a human colonic model. Although the in vitro assays using the RAW 264.7 macrophage cell line did not demonstrate direct immunomodulatory properties, the in vivo assays using a Dextran Sulphate Sodium (DSS)-induced colitic mice model showed clear immunomodulatory and protective effects of this strain.

Nutrients

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