Scientific Publications
Protective Effects of Lactobacillus plantarum CCFM8610 against Chronic Cadmium Toxicity in Mice Indicate Routes of Protection besides Intestinal Sequestration
Applied and Environmental Microbiology, 80 4063-4071, 4063-4071
Our previous study confirmed the ability of Lactobacillus plantarum CCFM8610 to protect against acute cadmium (Cd) toxicity in mice. This study was designed to evaluate the protective effects of CCFM8610 against chronic Cd toxicity in mice, and to give insights into the protection mode of this strain. Experimental mice were divided into two groups and exposed to Cd for 8 weeks via drinking water or intraperitoneal injection. Both groups were further divided into four sub-groups: control, Cd-only, CCFM8610-only, and Cd plus CCFM8610. Levels of Cd were measured in feces, liver, and kidney, and alterations to several biomarkers of Cd toxicity were noted. The results showed that when Cd was introduced orally, co-treatment with Cd and CCFM8610 effectively decreased intestinal Cd absorption, reduced Cd accumulation in tissue, alleviated tissue oxidative stress, recovered hepatic and renal damage and ameliorated the corresponding histopathological changes. When Cd was introduced intraperitoneally, administration of CCFM8610 did not impact on tissue Cd accumulation or recover the activities of antioxidant enzymes. However, CCFM8610 still offered protection against oxidative stress and reversed the alterations of Cd toxicity biomarkers and tissue histopathology. These results suggest that CCFM8610 is effective against chronic cadmium toxicity in mice. Besides intestinal Cd sequestration, CCFM8610 treatment offers direct protection against Cd-induced oxidative stress. We also provide evidence that the latter is unlikely to be mediated via the protection against Cd-induced alteration of antioxidant enzyme activities.
Applied and Environmental Microbiology, 80 4063-4071, 4063-4071
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