Quinolone-resistant gyrase mutants demonstrate decreased susceptibility to triclosan.

Webber M. A., Buckner M. M. C., Redgrave L. S., Ifill G., Mitchenall L. A., Webb C., Iddles R., Maxwell A., Piddock L. J. V.. (2017)

The Journal of antimicrobial chemotherapy, 72, 2755-2763

Cross-resistance between antibiotics and biocides is a potentially important driver of MDR. A relationship between susceptibility of Salmonella to quinolones and triclosan has been observed. This study aimed to: (i) investigate the mechanism underpinning this; (ii) determine whether the phenotype is conserved in Escherichia coli; and (iii) evaluate the potential for triclosan to select for quinolone resistance.

The Journal of antimicrobial chemotherapy, 72, 2755-2763

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