Suppression of LPS-induced transcription and cytokine secretion by the dietary isothiocyanate sulforaphane.

Folkard D. L., Melchini A., Traka M. H., Al-Bakheit A., Saha S., Mulholland F., Watson A., Mithen R. F.. (2014)

Molecular Nutrition and Food Research, 58 (12), 22862296

Diets rich in cruciferous vegetables are associated with lower levels of pro-inflammatory cytokines, which may contribute to potential health-promoting properties of these vegetables. We investigate whether sulforaphane (SF), an isothiocyanate (ITC) obtained from broccoli, could suppress LPS-induced transcription and subsequent pro-inflammatory cytokine secretion at a physiologically relevant concentration using in vitro models of chronic inflammation.

Molecular Nutrition and Food Research, 58 (12), 22862296

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