Vasorelaxant activity of twenty-one physiologically relevant (poly)phenolic metabolites on isolated mouse arteries.

Van Rymenant E., Grootaert C., Beerens K., Needs P. W., Kroon P. A., Kerimi A., Williamson G., García-Villalba R., González-Sarrías A., Tomas-Barberan F., Van Camp J., Van de Voorde J.. (2017)

Food & function, 8, 4331-4335

Polyphenols are beneficial for health, but are metabolised after consumption. We compared the vasorelaxant capacity of twenty-one physiologically relevant polyphenol metabolites in isolated mouse arteries. Hesperetin, urolithins and ferulic acid-4-O-sulfate - not their glucuronidated forms or ferulic acid - caused vasorelaxation. Therefore, we advise the use of relevant conjugates in future mechanistic research.

Food & function, 8, 4331-4335

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