Vitamin B12 Levels Association with Functional and Structural Biomarkers of Central Nervous System Injury in Older Adults.

Beaudry-Richard A, Abdelhak A, Saloner R, Sacco S, Montes SC, Oertel FC, Cordano C, Jabassini N, Ananth K, Gomez A, Keihani A, Chapman M, Javvadi S, Saha S, Staffaroni A, Songster C, Warren M, Boscardin JW, Kramer J, Miller B, Miller JW, Green R, Green AJ. (2025)

Annals of neurology

Vitamin B12 (B12) plays a critical role in fatty- and amino-acid metabolism and nucleotide synthesis. While the association between B12 deficiency and neurological dysfunction is well-known, the exact threshold for adequacy remains undefined in terms of functional impairment and evidence of injury. The objective was to assess whether B12 levels within the current normal range in a cohort of healthy older adults may be associated with measurable evidence of neurological injury or dysfunction.

Annals of neurology

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