Within the Quadram Institute, we are looking to contribute to efforts to reduce the impact and burden of liver disease by understanding the links between gut health, diet and the liver.

Liver disease affects around 2 million people in the UK each year, causing over 10,000 premature deaths, and, unlike other chronic diseases, deaths from liver disease are increasing.

Within the Quadram Institute, we are contributing to efforts to reduce the impact and burden of liver disease by understanding the links between gut health, diet and the liver. We are focusing on evidence that links intestinal dysfunction and inflammation with liver disease, to understand the mechanism of this communication, how it relates to metabolism, and develop targeted therapies to counter these effects.

We are also applying our body of research into food bioactives to investigate how bioactive compounds derived from foods regulate metabolism, including hepatic metabolism and the way the body metabolises lipids.

Targeting liver disease

Research Leaders Working on Liver/lipid disease

Berazza group

Naiara Beraza

Mechanisms regulating the gut-liver axis during health and disease

Kroon group

Paul Kroon

Health benefits of dietary polyphenols

Richard Mithen

Food chemistry and human health

Narbad group

Arjan Narbad

Translational microbiome

Muller Group

Michael Müller

Molecular nutrition of the gut-liver-brain axis

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