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Quadram Institute Bioscience provides a stimulating and rewarding environment to work in. Research Group Leaders lead small teams that use multidisciplinary approaches to tackling major societal challenges of treating disease , food innovation & improving health.
The Quadram Institute is part of the Norwich Research Park, which is home to 6 institutions carrying out world-leading research, an internationally renowned university, a major hospital with clinical research facilities and around 30 science and IT based businesses. With over 11,000 people including 3,000 scientists and clinicians and an annual research spend of over £100 million, the Norwich Research Park is Europe’s leading centre for research in Food, Health and the Environment.
Quadram Institute Bioscience benefits from its location on the edge of Norwich, combining a pleasant location set in 230 hectares of parkland with proximity to Norwich, a vibrant city that mixes the past and the future to make an inspiring place to live and work.
At Quadram Institute Bioscience we are committed to equality, diversity and inclusion. As part of that commitment we have signed up to the Athena SWAN Charter and we are working towards our application for Bronze status in late 2021. Athena SWAN was originally established to encourage and recognise commitment to advancing women’s careers in science, technology, engineering, maths, and medicine (STEMM). The Charter now includes addressing gender equality more broadly, not just the barriers to progression that affect women.
As a Disability Confident employer, we guarantee to offer an interview to all disabled applicants who meet the essential criteria for our vacancies.
Applications Close: 25 October 2021
A long (sequence) read: high throughput bacterial sequencing (LANGRIDGE_Q21DART)
In this project, Campylobacter and Salmonella isolates from diarrhoeal stool specimens will be investigated by applying high throughput HMW DNA extraction and long read sequencing technologies. Sequence data will be analysed with informatic methods and interpreted by comparison with publicly available data at national...
DetailsApplications Close: 22 November 2021
Probiotics and Pathogens – A Microbial Tug of War for the Host (GILMOUR_Q22DTP)
We are not alone when it comes to fighting off infections – our commensal gut microbiota very likely provides a protective effect against invading bacterial pathogens. Bifidobacterium are a foundational microbiota genus influencing microbial community dynamics and host immune development. Our group has been...
DetailsApplications Close: 22 November 2021
Ultra-resolved metagenomics of complex communities (HILDEBRAND_Q22DTP)
We are looking for a highly motivated and scientifically minded student, to work in a hybrid wet lab (60%) and bioinformatics (40%) project on cutting edge metagenomics. In the 4-year PhD project, the candidate will explore fungal and bacterial strains in the human gut,...
DetailsApplications Close: 22 November 2021
Understanding inhibition of the gut microbiota metabolism of carnitine by pomegranate (KROON_Q22DTP)
The human gut microbiota is actively involved in the metabolism of dietary compounds, often into metabolites that benefit the host (e.g. short chain fatty acids). However, the gut microbiota-dependent formation of trimethylamine (TMA) from L-carnitine and choline results in an atherogenic metabolite, TMA-N-oxide (TMAO)....
DetailsApplications Close: 22 November 2021
Can we use bacteriocins to improve gut health? (NARBAD_Q22DTP1)
Many bacteria produce antimicrobial compounds to help them compete in mixed communities. Antimicrobial peptides called bacteriocins from food and dairy strains have already been exploited successfully to prevent food poisoning or mastitis. Gene clusters producing these bacteriocins are increasingly being discovered in gut bacteria...
DetailsApplications Close: 22 November 2021
Are bacteria building toxic biofilms in your gut? (NARBAD_Q22DTP2)
Think of a corroded pipe. Now think of an inflamed gut. These conditions may be caused by similar bacteria. Sulphate reducing bacteria (SRB) are anaerobic bacteria, common in the environment and the gastrointestinal tract. They produce corrosive hydrogen sulphide gas, which is known to...
DetailsApplications Close: 22 November 2021
How a complex angiogenic network is governed during vascular development (ROBINSON_Q22DTP1)
Angiogenesis is the formation of blood vessels from pre-exisitng vessels. It is essential for maintaining healthy physiological processes and for the revascularisation of tissues following an injury. Our research group focuses on investigating the molecular basis of angiogenesis and we have recently identified a...
DetailsApplications Close: 22 November 2021
Location location location – how genome position affects gene expression (WEBBER_Q22DTP)
Bacterial genomes have evolved over billions of year to allow efficient expression of the right genes at the right times. It has become clear that the same gene, placed in different locations around a bacterial chromosome can display very different levels of expression. The...
DetailsApplications Close: 22 November 2021
Molecular structuring of foods to feed the gut microbiome (WARRENF_Q22CASE)
Developing the latest generation of foods requires detailed structural and chemical insights into the molecular scale structuring within a food, as well as the application of novel processing methods. This will allow the creation of novel foods which can be targeted to deliver highly...
DetailsApplications Close: 22 November 2021
Engineering enhanced vitamin synthesis in bacteria (WARRENM_Q22CASE)
This project aims to apply synthetic biology and metabolic engineering strategies to one of the most complex biochemical pathways found in nature in order to address a current need for a cheaper and more reliable source of vitamin B12, the so-called anti-pernicious anaemia factor....
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